A cFos activation map of remote fear memory attenuation
نویسندگان
چکیده
منابع مشابه
The neurocircuitry of remote cued fear memory.
Memories of threatening, fear-evoking events can persist even over a lifetime. While fear memory is widely considered to be a highly persistent and durable form of memory, its circuits are not. This article reviews the dynamic temporal representation of remote fear memory in the brain, at the level of local circuits and distributed networks. Data from the study of Pavlovian cued fear conditioni...
متن کاملStability of recent and remote contextual fear memory.
Following initial encoding, memories undergo a prolonged period of reorganization. While such reorganization may occur in many different memory systems, its purpose is not clear. Previously, we have shown that recall of recent contextual fear memories engages the dorsal hippocampus (dHPC). In contrast, recall of remote contextual fear memories engages a number of different cortical regions, inc...
متن کاملExtinction partially reverts structural changes associated with remote fear memory.
Structural synaptic changes occur in medial prefrontal cortex circuits during remote memory formation. Whether extinction reverts or further reshapes these circuits is, however, unknown. Here we show that the number and the size of spines were enhanced in anterior cingulate (aCC) and infralimbic (ILC) cortices 36 d following contextual fear conditioning. Upon extinction, aCC spine density retur...
متن کاملThe Maintenance of Established Remote Contextual Fear Memory Requires ERK5 MAP Kinase and Ongoing Adult Neurogenesis in the Hippocampus
Adult neurogenesis in the dentate gyrus of the hippocampal formation has been implicated in several forms of hippocampus-dependent memory. However, its role in the persistence of remote memory is unknown. Furthermore, whether the hippocampus plays a role in maintaining remote contextual memories is controversial. Here we used an inducible gene-specific approach for conditional deletion of erk5 ...
متن کاملActivation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning.
Although much has been learned about the neurobiological mechanisms underlying Pavlovian fear conditioning at the systems and cellular levels, relatively little is known about the molecular mechanisms underlying fear memory consolidation. The present experiments evaluated the role of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling cascade in the a...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2018
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-018-5000-y